Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and geneticdiabetic mice

Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and geneticdiabetic mice. Kim MJ, Kim HK.

Department of Obesity management, Graduate School of Obesity Science, Dongduk Women's University, 23-1 Wolkgukdong, Seoul, 136-714, South Korea.

Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic beta-cell dysfunction found in diabetes. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes.Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in two different diabetic animal models. The genetically diabeticmouse strain C57BL/6J-db/db (db/db) and streptozotocin (STZ)-induced diabetic mouse were used as insulin deficient type 1 and insulin resistant type 2 animal model, respectively. However, ERW fail to affect blood insulin levels in STZ-diabetic mice whereas blood insulin level was markedly increased in genetically diabetic db/db mice. This improved blood glucose control could result from enhanced insulin sensitivity, as well as increased insulin release. 

The present data suggest that ERW, provided as a drinking water, significantly reduced the blood glucose concentration and improved glucose tolerance in both animal models.ERW may function as an orally effective anti-diabetic agent and merit further studies on its precise mechanism.

PMID: 16945392 [PubMed - indexed for MEDLINE]

CLINICAL STUDY RESULTS SHOWING  MICRO-CLUSTERED, HEXAGONAL WATER
 HYDRATION  IMPROVEMENT IN TYPE 2 DIABETICS

Asia Pac J Clin Nutr. 2004;13(Suppl):S128.
Wang ZY, Zhou ZC, Zhu KN, Wang X, Pan JG, Lorenzen LH, Zhou MC.
Center for Bio-signaling & System Research, New Jersey Institute of Technology, NJ 07102, USA

In 2003 the Chinese Health Care Science and Technology Society organized an international cooperative research project on "Hydration and Health" to compare distilled water (DW) and micro-clustered water (MW). Recent bioelectrical impedance analysis (BIA) studies also showed that diabetics had a lower ratio of intracellular water (ICW) / extracellular water (ECW).

A total 336 type-2 diabetics (plasma glucose level =7.0 mmol/L) from five hospitals were recruited in a randomized, double-blind trial.All the subjects received 250 ml of MW or DW twice daily for 4 weeks. To avoid over-dose absorption, subjects were advised to not take medications within 30 minutes after consumption of the test waters. BIA (RJL, USA) and other clinical markers were performed weekly.

It was observed that MW consumption improved cell water distribution (ICW/ECW), basal metabolism rate (BMR), phase angle (PA) and cell capacitance (CP) during the 4 week testing period. The relative small size of the water cluster may be one of the mechanisms which leads to improved cell structure and function.

In comparison with the rate change from baseline, the P value (MW vs DW) of ICW/ECW, BMR, PA and CP were 0.04, 0.003, 0.005 and 0.003, respectively.

In this study, about 45% of subjects had higher plasma glucose level >8.3 mmol/L).

In comparison with the means of above four BIA measurements at the end of experiment, the P value (MW vs DW) were 0.025, 0.022, 0.007 and 0.009, respectively. Two repeating NMR analysis showed that the half-width of the oxygen (17) NMR spectrum were 64 and 67HZ, respectively, approximating normal saline, plasma and fresh natural spring water, while NMR values of DW and most purified waters exceeded 100 HZ.